Background Although pediatric SARS-CoV-2 infection is usually mild; children with chronic conditions are at increased risk of severe disease. Myeloid Cell Leukemia-1 (MCL-1), a key regulator of mitochondrial apoptosis, is expressed as one anti-apoptotic isoform (MCL-1 L) and two pro-apoptotic isoforms (MCL-1 S and MCL-1ES), but their regulation in pediatric viral infections remains unclear. Methods and results We assessed MCL-...

Sporotrichosis caused by Sporothrix brasiliensis is a highly virulent zoonotic mycosis rapidly expanding in Brazil, with increasing records in Pará since 2018. The reference diagnosis relies on culture and the time-consuming induction of fungal dimorphism, which delays taxonomic confirmation for weeks. The objective of the study was to develop and validate an in-house spectral library by MALDI-TOF MS for the rapid identificati...

Marine pollution caused by plastic waste is a global issue. Improperly discarded plastics often end up in seas and oceans, where they become colonized by a microbial biofilm known as the Plastisphere. In this environment, especially in places where sewage is discharged untreated into water bodies, pathogenic microorganisms and those carrying antimicrobial resistance genes (ARGs) can settle and spread over long distances. To as...

Sporothrix species are the etiological agents of sporotrichosis, an emerging fungal disease of medical and veterinary importance. Molecular surveillance using publicly available databases enables the monitoring of pathogen dissemination and the identification of genetic and epidemiological patterns, particularly in endemic regions. This study aimed to perform an integrative analysis of clinical, epidemiological and phylogeneti...

Biodiversity monitoring programs need to deliver accurate, timely, and actionable predictions. To establish a predictive monitoring program for deep‐sea benthos of the Santos Basin, Brazil, we developed a two‐stage structured model that allowed comparison of biodiversity predictions obtained from environmental simulations (2M‐Sim). We also modeled the environmental variables as a function of spatial and temporal variables and...

Rimonabant (SR141716A), an inverse agonist of the cannabinoid receptor type 1 (CB 1 ), once approved for treating obesity and metabolic disorders, was withdrawn shortly after due to psychiatric and psychological adverse events (PPAEs), including depression and suicidality. Although its primary pharmacological mechanism of action is well-characterized, the molecular basis underlying these neuropsychiatric effects remains unclea...

Purpose The management of biogenic residues in a way that extends the lifetime of carbon within the systems is a focus of the present work. Different waste management systems are assessed in terms of GHG emissions and removals, aiming to identify that with the lowest impact on climate change. Methods A life cycle comparative analysis is performed, assessing the mitigation of the impact on climate change of the current waste ma...

Air pollution and climate change remain critical environmental challenges, particularly in urban areas, where conventional monitoring networks are often too sparse to capture fine‐scale exposure gradients due to their high operational costs. Epiphytic lichen biomonitoring provides a valuable complementary approach, as these organisms are sensitive to both air pollutants and climate conditions. Despite the existence of a standa...

The application of vibrational microspectroscopy to the study of in vitro mesenchymal stem cells (MSC) osteogenic differentiation is a promising approach towards the understanding of the molecular processes involved in bone fabrication. Both infrared (IR) and Raman microspectroscopies have been applied, with a clear predominance of the latter. Bone marrow MSC have been the target of most studies, followed by those originating...