Cryopreserved human heart valves and cardiovascular tissues (homografts) are essential for the surgical treatment of congenital and acquired valvular diseases, particularly in pediatric patients, where prosthetic options are limited. To address the clinical demand for high-quality grafts in Israel, Sheba Medical Center, the largest tertiary care hospital in Israel, established a Good Manufacturing Practice (GMP) compliant Card...

Musculoskeletal allografts are becoming increasingly essential in orthopaedic and reconstructive surgery. A significant source of these allografts is tissues retrieved from deceased donors. While contributing substantially to the pool of allografts, these tissues are at increased risk of bacterial contamination. This risk is further amplified when tissues are procured from field casualties. In this study, we performed a side-b...

Cardiovascular allografts are essential for patients with severe cardiovascular diseases. Yet, microbial contamination of the grafts poses a life-threatening risk to recipients. Tissue banks utilize various decontamination methods during cardiovascular tissue processing, often involving antibiotic solutions. This study compares the efficacy of an in-house prepared antibiotic cocktail (tissue bank cocktail) and a commercially a...