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Inflammation Research · 2025 · Vol. 74 · Issue 1 · Springer
Background Adenosine, an ATP degradation product, is a sleep pressure factor. The adenosine 1 receptor (A1R) reports sleep need. Histaminergic neurons (HN) of the tuberomamillary nucleus (TMN) fire exclusively during wakefulness and promote arousal. All of them express GABA A receptors and are inhibited by GABA. Does adenosine contribute to their silencing? Subjects and treatment Responses to adenosine were studied in mouse br...