Hitoshi Ito results 35
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Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinomaNARA Subscribed
Despite advancements in diagnostic and therapeutic strategies, lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality due to its aggressive metastatic potential. Extracellular superoxide dismutase (SOD3) is an antioxidant enzyme that regulates oxidative stress and is regarded as a tumor suppressor. However, studies have demonstrated that SOD3 can either promote or inhibit cell proliferation and survival...
In the metabolic pathway of chlorophylls (Chls), an enzyme called STAY-GREEN or SGR catalyzes the removal of the central magnesium ion of Chls and their derivatives to their corresponding free bases, including pheophytins. The substrate specificity of SGR has been investigated through in vitro reactions using Chl-related molecules. However, information about the biochemical properties and reaction mechanisms of SGR and its sub...
Feline morbillivirus (FeMV) was identified for the first time in cats in 2012 in Hong Kong. Although its association with chronic kidney disease in cats has attracted the attention of researchers, its clinical significance as an acute infection has not been reported. Previously, we reported FeMV detection using next-generation sequence-based comprehensive genomic analysis of plasma samples from cats with suspected acute febril...
Species-specific ecological traits in fishes are likely to vary between populations or stocks due to differences in regional oceanic conditions, such as latitudinal temperature. We examined potential intraspecific differences in the swimming performance and metabolism of Pacific chub mackerel ( Scomber japonicus ) from the Northwest and Northeast Pacific stocks, which are distributed on opposite sides of the North Pacific at s...
Vertical turbulent nitrate flux from direct measurements in the western subarctic and subtropical gyres of the North PacificNARA Subscribed
Vertical turbulent nitrate fluxes were estimated in the western North Pacific from direct measurements of vertical turbulent mixing and vertically continuous nitrate profiles during the summer of 2008. We made three north–south transects that covered the area from the subarctic to the subtropics including a section along the Emperor Sea Mounts. Subsurface fluxes generally showed an increasing trend with increasing vertical gra...