Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. To investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma, we constructed RIG-I knockout, RIG-I -overexpressing B16-F10...

An increasing number of epidemiological studies have suggested that birth weight (BW) may be a determinant of bone health later in life, although the underlying genetic mechanism remains unclear. Here, we applied a pleiotropic conditional false discovery rate (cFDR) approach to the genome-wide association study (GWAS) summary statistics for lumbar spine bone mineral density (LS BMD) and BW, aiming to identify novel susceptibil...

The Huangmaohai estuary (HE) is a funnel-shaped microtidal estuary in the west of the Pearl River Delta (PRD) in southern China. Since China reformed and opened up in 1978, extensive human activities have occurred and greatly changed the estuary's topography and modified its hydrodynamics. In this study, we examined the morphological evolution by analyzing remote sensing data with ArcGIS tools and studied the responses of hydr...