Ankylosing spondylitis (AS) is a chronic, immune-mediated inflammatory disorder primarily affecting the axial skeleton. It is characterized by bony fusion and syndesmophyte formation of the spine, leading to compromised mobility, reduced quality of life and increased mortality. However, the underlying immune dysregulation in AS remains poorly understood. We comprehensively profiled the peripheral immune landscape of 30 patient...

Coastal sediment ecosystems function as dynamic interfaces for land-sea interactions, harboring highly complex microbial communities which support vital ecological functions. However, the mechanisms governing microbial diversity maintenance and cross-trophic community assembly at large spatial scales remain poorly explored. In this study, a high-throughput sequencing approach was employed to analyze the bacterial, fungal and p...