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Deep Immunophenotyping Unravels the Double Negative T cells and PD-1-Mediated Inflammatory Exhaustion in Ankylosing SpondylitisNARA Subscribed
Ankylosing spondylitis (AS) is a chronic, immune-mediated inflammatory disorder primarily affecting the axial skeleton. It is characterized by bony fusion and syndesmophyte formation of the spine, leading to compromised mobility, reduced quality of life and increased mortality. However, the underlying immune dysregulation in AS remains poorly understood. We comprehensively profiled the peripheral immune landscape of 30 patient...
Strength Degradation and Chloride Ion Diffusion Behavior of Concrete Under Simulated Marine ExposureOA Marine
Chloride-induced deterioration is a major threat to the durability of marine concrete structures, especially in tidal and submerged zones. This study simulated these environments by immersing C45 concrete specimens in NaCl solutions (5%, 10%, 15%) under both constant immersion and wet–dry cycles. Compressive strength tests, low-field NMR for pore structure, chloride ion profiling, and SEM-EDS analyses were conducted. A modifie...