Ankylosing spondylitis (AS) is a chronic, immune-mediated inflammatory disorder primarily affecting the axial skeleton. It is characterized by bony fusion and syndesmophyte formation of the spine, leading to compromised mobility, reduced quality of life and increased mortality. However, the underlying immune dysregulation in AS remains poorly understood. We comprehensively profiled the peripheral immune landscape of 30 patient...

Special orthogonal lateral-intake pumping stations on coastal plains face severe lateral deflection and recirculation in the approach channel and forebay. Their underlying evolutionary mechanisms remain unclear, and conventional rectification methods cause substantial hydraulic losses. Using numerical simulations and hydraulic model experiments, this study investigates these unfavorable flow patterns and proposes an original C...