Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives, talaronins A-E ( 1–5 ) and three new xanthone derivatives, talaronins F–H ( 6–8 ), together with 16 known compounds ( 9–24 ), were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362. The structures were elucidated by analysis of spectros...