Honglin Han results 28
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In this study, a new cell line named yellowfin sea bream muscle (YSBM) was successfully established by using muscle tissue from yellowfin seabream, Acanthopagrus latus , a widespread saline fish cultivated in China. The YSBM cell line was subcultured more than 100 passages and appeared to be suitable for researching gene functions in vitro, as it was able to be transfected successfully with pEGFP‐N3 plasmid. Additionally, YSBM...
Objectives and design As an interferon-inducible protein, Viperin has broad-spectrum antiviral effects and regulation of host immune responses. We aim to investigate how Viperin regulates interferon-γ (IFN-γ) production in macrophages to control Mycobacterium tuberculosis (Mtb) infection. Methods We use Viperin deficient bone-marrow-derived macrophage (BMDM) to investigate the effects and machines of Viperin on Mtb infection....
SNX5 is a protein that is involved in endosomal sorting, signal transduction and endocytosis pathways. However, the roles of fish SNX5 were largely unknown. In this study, we identified an SNX5 homolog (EcSNX5) from an orange-spotted grouper (E. coioides) and investigated its role during viral infection. EcSNX5 encoded 412 amino acids with a PX domain and a BAR domain. In addition, it shared high identities with other known fi...
As a product of hydrothermal mineralization at spreading centers, seafloor massive sulfides (SMS) have become a research hotspot in the field of prospecting and exploring deep-sea mineral resources owing to their enrichment of various strategic metals. Since hydrothermal circulation changes the magnetic properties of host rocks and can generate magnetic anomalies, near-bottom magnetic surveying is an effective method to determ...
Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infectionNARA Subscribed
Objectives and design Dendritic cells (DCs) are one of the key immune cells in bridging innate and adaptive immune response against Mycobacterium tuberculosis (Mtb) infection. Interferons (IFNs) play important roles in regulating DC activation and function. Virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible (Viperin) is one of the important IFN-stimulated genes (ISGs), and elicits host defense aga...