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Background Aspects of the gut microbiome, including presence of specific bacterial species and overall community structure, have been linked to the etiology and prognosis of colorectal cancer (CRC). Less is known about the epidemiologic risk factors that are associated with the composition of the microbiota in invasive colorectal tumors. Methods Using tumor and paired normal colorectal tissue samples from a subset of participa...
Marine megafauna species are affected by a wide range of anthropogenic threats. To evaluate the risk of such threats, species’ vulnerability to each threat must first be determined. We build on the existing threats classification scheme and ranking system of the International Union for Conservation of Nature (IUCN) Red List of Threatened Species by assessing the vulnerability of 256 marine megafauna species to 23 at‐sea threat...
The U.S. Ecosystem‐Based Fisheries Management Policy and Road Map: Assessing Progress and Applying Lessons LearnedNARA Subscribed
The need for ecosystem‐based fisheries management (EBFM) is growing more urgent as environmental changes, species shifts, new ocean uses, and other factors force oceans toward novel states. In the United States, the National Oceanic and Atmospheric Administration's National Marine Fisheries Service (NOAA Fisheries) developed an EBFM Policy in 2016, accompanied by a Road Map of 49 action items, to support marine ecosystem‐based...
We assembled a European bread wheat ( Triticum aestivum L.) association mapping panel ( n = 480) genotyped using a 90,000 feature single nucleotide polymorphism array, with the aim of identifying genetic loci controlling resistance to four fungal diseases: yellow (stripe) rust (YR), brown (leaf) rust (BR), Septoria tritici blotch (ST) and powdery mildew (PM). Simulations showed our panel to have good power to detect genetic lo...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Phylogeography of Microphis retzii (Bleeker, 1856) and Microphis brachyurus (Bleeker, 1854) in the PacificNARA Subscribed
Syngnathidae are a charismatic family of teleost fishes, represented by seahorses, seadragons, and pipefishes. Syngnathidae are mainly composed of marine species, but about 30 species of pipefishes inhabit freshwater insular environments of the Indo‐Pacific realm. Recent research has shown that some freshwater pipefish species are amphidromous and exhibit high intraspecific divergences across their distribution range, like Mic...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
The common dolphin ( Delphinus delphis ) is a widely distributed species exhibiting extensive morphological diversity, with previous taxonomies recognizing multiple Delphinus species primarily based on relative beak length. We sequenced mitochondrial genomes of D. delphis morphotypes from multiple regions, calculated mitogenome nucleotide diversity (π = 0.00504), dated Delphinus mitogenome diversification to 1.27 mya, and cond...
Wilder rangelands as a natural climate opportunity: Linking climate action to biodiversity conservation and social transformationNARA Subscribed
Rangelands face threats from climate and land-use change, including inappropriate climate change mitigation initiatives such as tree planting in grassy ecosystems. The marginalization and impoverishment of rangeland communities and their indigenous knowledge systems, and the loss of biodiversity and ecosystem services, are additional major challenges. To address these issues, we propose the wilder rangelands integrated framewo...
A new winter wheat genetic resource harbors untapped diversity from synthetic hexaploid wheatNARA Subscribed
Key message The NIAB_WW_SHW_NAM population, a large nested association mapping panel, is a useful resource for mapping QTL from synthetic hexaploid wheat that can improve modern elite wheat cultivars. Abstract The allelic richness harbored in progenitors of hexaploid bread wheat ( Triticum aestivum L.) is a useful resource for addressing the genetic diversity bottleneck in modern cultivars. Synthetic hexaploid wheat (SHW) is c...
Land surface conductance linked to precipitation: Co‐evolution of vegetation and climate in Earth system modelsNARA Subscribed
Vegetation and precipitation are known to fundamentally influence each other. However, this interdependence is not fully represented in climate models because the characteristics of land surface (canopy) conductance to water vapor and CO 2 are determined independently of precipitation. Working within a coupled atmosphere and land modelling framework (CAM6/CLM5; coupled Community Atmosphere Model v6/Community Land Model v5), we...