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Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer’s disease and related dementias in a community cohortNARA Subscribed
Hypertension in midlife is associated with increased dementia risk, yet its relationship with early pathological changes of Alzheimer’s disease and related dementias (ADRD) remains unclear. Unlike office blood pressure (BP), 24-h ambulatory BP (ABPM) may better reflect cardiovascular risk, but associations between 24-h BP measures with ADRD biomarkers are unknown. This cross-sectional study examined associations between BP and...
Factor analysis of multimodal MRI, biofluid, and vascular biomarkers reveals latent constructs of brain healthNARA Subscribed
Individual imaging and fluid biomarkers provide insights into specific components of brain health, but integrated multimodal approaches are necessary to capture the complex, interrelated biological systems that contribute to brain homeostasis and neurodegenerative disease. Using data from the Brain and Cognitive Health (BACH) cohort study ( N = 127; mean age = 67 years, 68% women), we performed an exploratory factor analysis t...
The Role of Verbal Fluency in the Cerebellar Cognitive Affective Syndrome Scale in Friedreich AtaxiaNARA Subscribed
Cerebellar pathology engenders the disturbance of movement that characterizes Friedreich ataxia (FRDA), yet the impact of cerebellar pathology on cognition in FRDA remains unclear. Numerous studies have unequivocally demonstrated the role of the cerebellar pathology in disturbed cognitive, language and affective regulation, referred to as Cerebellar Cognitive Affective Syndrome (CCAS), and quantified by the CCAS-Scale (CCAS-S)...
MR Imaging in Ataxias: Consensus Recommendations by the Ataxia Global Initiative Working Group on MRI BiomarkersNARA Subscribed
With many viable strategies in the therapeutic pipeline, upcoming clinical trials in hereditary and sporadic degenerative ataxias will benefit from non-invasive MRI biomarkers for patient stratification and the evaluation of therapies. The MRI Biomarkers Working Group of the Ataxia Global Initiative therefore devised guidelines to facilitate harmonized MRI data acquisition in clinical research and trials in ataxias. Recommenda...
CorrectionNARA Subscribed
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