Ian R. Simpson results 11
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Germline copy number variants and endometrial cancer riskNARA Subscribed
Known risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown. We conducted a genome-wide analysis of rare CNVs overlapping gene regions in 4115 endometrial cancer cases and 17,818 controls to identify functionally relevant variants associated with disease. We identif...
Effects of interactions between anthropogenic stressors and recurring perturbations on ecosystem resilience and collapseNARA Subscribed
Insights into declines in ecosystem resilience and their causes and effects can inform preemptive action to avoid ecosystem collapse and loss of biodiversity, ecosystem services, and human well‐being. Empirical studies of ecosystem collapse are rare and hampered by ecosystem complexity, nonlinear and lagged responses, and interactions across scales. We investigated how an anthropogenic stressor could diminish ecosystem resilie...
SoilTemp: A global database of near‐surface temperatureNARA Subscribed
Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long‐term average thermal conditions at coarse spatial resolutions only. Hence, many climate‐forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to...
Structural and sampling uncertainty in observed UK daily precipitation extremes derived from an intercomparison of gridded data setsNARA Subscribed
This paper compares multiple gridded data sets of daily UK precipitation to evaluate structural uncertainty in our reconstructions of historical rainfall. The data sets compared reflect two different sampling strategies and three different grid interpolation methods. In order to separate the influence of sampling and interpolation uncertainties, one of the data sets (produced by the Met Office) has been recreated using the sam...
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