This study investigates the age-based life-history traits of two groundfish species, the spotted moray eel ( Gymnothorax moringa ) and squirrelfish ( Holocentrus adscensionis ), found in Ascension Island and St Helena. Both islands are part of the UK Overseas Territories (UKOTs) and are known for their fish biodiversity. The research aims to provide essential life-history information to support sustainable management of these...

Known risk loci for endometrial cancer explain approximately one third of familial endometrial cancer. However, the association of germline copy number variants (CNVs) with endometrial cancer risk remains relatively unknown. We conducted a genome-wide analysis of rare CNVs overlapping gene regions in 4115 endometrial cancer cases and 17,818 controls to identify functionally relevant variants associated with disease. We identif...

Variability in seasonal weather in north‐west Europe is substantially determined by jet stream variability. The North Atlantic Oscillation (NAO) has been well studied as a key representation of this jet stream variability, but other circulation indices are also important. Here the first three principal component empirical orthogonal functions (EOFs) of 500 hPa geopotential height (GPH), which broadly correspond to the NAO, the...

The Avoca Tank orebody is one of a series of copper-rich orebodies occurring within the Girilambone Cu province of central New South Wales. Mineralisation at Avoca Tank is hosted within several narrow, chloritic, greenschist-facies shear zones which developed ~430 Ma (U-Pb titanite) within metasedimentary rocks around the margins of an Ordovician (ca. 470 Ma) mafic sill complex. Mineralisation at Avoca Tank preserves an early...

Background While the majority of patients with atopic dermatitis (AD) achieve disease control with dupilumab treatment, there is variability in which patients achieve clear disease. The predictors of these responses are currently unclear. Integrated models were developed to evaluate the exposure–response (E-R) relationship of dupilumab in children, adolescents, and adults with AD. Methods Data from six Phase II and III clinica...

Insights into declines in ecosystem resilience and their causes and effects can inform preemptive action to avoid ecosystem collapse and loss of biodiversity, ecosystem services, and human well‐being. Empirical studies of ecosystem collapse are rare and hampered by ecosystem complexity, nonlinear and lagged responses, and interactions across scales. We investigated how an anthropogenic stressor could diminish ecosystem resilie...

Given their strong affinity for the skeleton, trace elements are often stored in bones and teeth long term. Diet, geography, health, disease, social status, activity, and occupation are some factors which may cause differential exposure to, and uptake of, trace elements, theoretically introducing variability in their concentrations and/or ratios in the skeleton. Trace element analysis of bioarchaeological remains has the poten...

Current analyses and predictions of spatially explicit patterns and processes in ecology most often rely on climate data interpolated from standardized weather stations. This interpolated climate data represents long‐term average thermal conditions at coarse spatial resolutions only. Hence, many climate‐forcing factors that operate at fine spatiotemporal resolutions are overlooked. This is particularly important in relation to...

The 2015 Gorkha Earthquake was a humanitarian disaster but also a cultural catastrophe that damaged and destroyed historic monuments across Nepal, including those within the Kathmandu Valley UNESCO World Heritage Property. In the rush to rebuild, traditionally constructed foundations are being removed and replaced with modern materials without assessments of whether these contributed to the collapse of a monument. Generally un...

This paper compares multiple gridded data sets of daily UK precipitation to evaluate structural uncertainty in our reconstructions of historical rainfall. The data sets compared reflect two different sampling strategies and three different grid interpolation methods. In order to separate the influence of sampling and interpolation uncertainties, one of the data sets (produced by the Met Office) has been recreated using the sam...