Objective Brain injury and neurodegenerative conditions are largely caused by oxidative damage and endoplasmic reticulum (ER) stress spurred on by hyperlipidemia. To lessen these consequences in the brains of hyperlipidemic rats, this study assesses the therapeutic potential of both rosuvastatin glycerosomes (RSV GLSMs) and niacin. Methods The study had five groups: control, hyperlipidemia induced by poloxamer 407 (P407), RSV...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that typically requires long-term drug treatment. The emerging role of glucagon-like peptide 1 (GLP-1) and its receptor agonists in gastrointestinal diseases has drawn much attention. A mouse model of acute colitis was conducted using a 7-day protocol of dextran sulfate sodium (DSS, 3% w/v in drinking water) administration. The efficacy of liraglutide (a GLP...