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Physiological Effects of Suspended Solids on Venerupis philippinarum and Argopecten irradiansOA Marine
Suspended solids are small particles transported in the water column, which can damage marine ecosystems and impair the health of aquatic organisms. This study evaluated the physiological responses of clams (Venerupis philippinarum) and Atlantic Bay scallops (Argopecten irradians) to suspended solid exposure. Four concentrations (100–1000 mg/L) were tested, with a control group maintained at 0 mg/L. At each time point (1, 2, 4...
Off-the-Shelf, Immune-Compatible Human Embryonic Stem Cells Generated Via CRISPR-Mediated Genome EditingNARA Subscribed
Human embryonic stem cells (hESCs) hold promise in regenerative medicine but allogeneic immune rejections caused by highly polymorphic human leukocyte antigens (HLAs) remain a barrier to their clinical applications. Here, we used a CRISPR/Cas9-mediated HLA-editing strategy to generate a variety of HLA homozygous-like hESC lines from pre-established hESC lines. We edited four pre-established HLA-heterozygous hESC lines and crea...