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Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout miceNARA Subscribed
Non-alcoholic fatty liver disease and atherosclerosis may share a common pathogenesis involving chronic IL-1β-induced inflammation. We aimed to evaluate the efficacy of diacerein, an IL-1 pathway inhibitor, in improving liver fibrosis, steatosis, and atherosclerosis in apolipoprotein E-knockout (apoE k/o) mice. ApoE k/o mice fed a high-fat diet (HFD) were divided into three groups based on diacerein dosage. Liver fat accumulat...
Application of Fibronectin-Coated Microparticles for Isolation of Human iPSC-Derived MSCsNARA Subscribed
BACKGROUND : Bone marrow–derived MSCs (BMMSCs) are limited by availability, donor variability, and age-related decline, highlighting the need for alternative MSC sources. Induced pluripotent stem cells (iPSCs) offer a scalable solution. This study introduces a novel three-dimensional culture platform based on fibronectin (FN)-coated microparticles to efficiently derive and expand human iPSC-derived MSCs (iMSCs). METHODS : The...
Pacific abalone (Haliotis discus hannai) is a widely cultured and economically important abalone species in aquaculture yet improving growth performance remains a major challenge for stable production. To clarify the molecular architecture associated with growth performance in Pacific abalone, we integrated transcriptome and genome-wide association study (GWAS) data from high-growth and low-growth groups showing significant gr...
Reliable identification of seafood species is critical for fisheries management and product authentication, especially when morphological characteristics are lost during processing. In this study, a multiplex PCR system was developed to distinguish seven cuttlefish species (six Sepia spp. and Sepiella inermis) commercially distributed in the Korean seafood market. Species identity was first confirmed by amplifying a mitochondr...
Evaluation and application of molecular marker sets for developing PHS-resistant wheat in KoreaNARA Subscribed
Pre-harvest sprouting (PHS) is a major constraint on wheat production in Korea, reducing grain quality and end-use value. To accelerate the development of PHS-resistant cultivars with improved agronomic performance, we employed a marker-assisted backcrossing (MABC) approach using molecular markers previously reported in the literature. For foreground selection, 81 molecular markers (74 KASP and 7 gel-based) targeting key genes...