In the era of the sixth mass extinction, reversing global biodiversity loss is of vital importance for life on Earth. In 2022, parties to the Convention on Biological Diversity (CBD) adopted the Kunming‐Montreal Global Biodiversity Framework (GBF), a strategic plan with 23 action‐oriented targets to be achieved by 2030. However, biodiversity action carries direct and indirect costs that are unevenly distributed globally. Moreo...

Cytochrome P450 (CYP)3A4 induction by drugs and pesticides plays a critical role in the enhancement of pyrrolizidine alkaloid (PA) toxicity as it leads to increased formation of hepatotoxic dehydro-PA metabolites. Addressing the need for a quantitative analysis of this interaction, we developed a physiologically-based toxicokinetic (PBTK) model. Specifically, the model describes the impact of the well-characterized CYP3A4 indu...

With the United Nations’ Agenda 2030, countries worldwide have committed to a set of Sustainable Development Goals (SDGs) to be achieved by 2030. Among them is SDG 15, known as Life on Land. What makes this SDG special is that several of its targets had been scheduled for completion by 2020– raising the question what should happen to these targets after 2020 as they have not yet been achieved. With the approaching 2023 SDG Sum...

Retrorsine is a hepatotoxic pyrrolizidine alkaloid (PA) found in herbal supplements and medicines, food and livestock feed. Dose-response studies enabling the derivation of a point of departure including a benchmark dose for risk assessment of retrorsine in humans and animals are not available. Addressing this need, a physiologically based toxicokinetic (PBTK) model of retrorsine was developed for mouse and rat. Comprehensive...