Purpose The main purpose was to identify clusters of adolescents with overweight or obesity characterized by the satisfaction of basic psychological needs, exercise-related barriers, and social support by family members and friends. This served the overarching goal of informing hypotheses for tailored research approaches in physical activity promotion considering a stronger focus on physical activity enjoyment. Methods Cross-s...

Alzheimer’s disease (AD) is presented as multiple clinical variants depending upon the rate of progression and familial background; however, the exact molecular mechanisms associated with these subtypes and their treatments are yet to be understood. The current study is based on a global proteome analysis of brain samples from patients ( n = 38) with rapidly progressive AD (rpAD—survival time < 3 years), sporadic AD (spAD—surv...

The development of the real-time quaking-induced conversion (RT-QuIC), an in vitro protein misfolding amplification assay, was an innovation in the scientific field of protein misfolding diseases. In prion diseases, these types of assays imitate the pathological conversion of the cellular prion protein (PrP C ) into a protease-resistant and/or amyloid form of PrP, called PrP resistant (PrP Res ). The RT-QuIC is an automatic as...

Fungi are highly diverse organisms, which provide multiple ecosystem services. However, compared with charismatic animals and plants, the distribution patterns and conservation needs of fungi have been little explored. Here, we examined endemicity patterns, global change vulnerability and conservation priority areas for functional groups of soil fungi based on six global surveys using a high‐resolution, long‐read metabarcoding...

Repetitive head impacts (RHI) are common in youth athletes participating in contact sports. RHI differ from concussions; they are considered hits to the head that usually do not result in acute symptoms and are therefore also referred to as “subconcussive” head impacts. RHI occur e.g., when heading the ball or during contact with another player. Evidence suggests that exposure to RHI may have cumulative effects on brain struct...

The extensive clinical and genetic heterogeneity of congenital limb malformation calls for comprehensive genome-wide analysis of genetic variation. Genome sequencing (GS) has the potential to identify all genetic variants. Here we aim to determine the diagnostic potential of GS as a comprehensive one-test-for-all strategy in a cohort of undiagnosed patients with congenital limb malformations. We collected 69 cases (64 trios, 1...

Anthropogenic climate change is affecting agriculture and crop production. The responses of horticultural and agricultural systems to changing climatic conditions can be non-linear and at times counter-intuitive. Depending on the characteristics of the system, the actual impact can arise as a result of a combination of climate hazards or compound events. Here, we show that compound events can lead to increased risk of frost da...