Introduction of immune checkpoint inhibitors (ICI) has improved overall survival (OS) for advanced non-small cell lung cancer (NSCLC). However, responses differ greatly amongst patients. Additional radiotherapy (RT) may promote tumor-specific immunity and synergize with ICI to improve tumor control. The multicenter phase II FORCE trial evaluated safety and efficacy of nivolumab with additional palliative radiotherapy (5 × 4 Gy...

Aim Global warming and deforestation are pushing species closer to their physiological limit, especially for species with habitat‐restricted life stages because sunlit areas have higher maximum temperatures. Here, we examined the critical thermal maximum (CT max ), and maximum environmental water temperature (T max ) of larvae from 29 anuran species across a latitudinal gradient (22–43° N) to test how latitude and habitat type...