Isabel Kim results 31
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The Seaward Migration of European Eel at a Continental Scale: A Europe‐Wide Biotelemetry Meta‐AnalysisNARA Subscribed
The European eel ( Anguilla anguilla L.) has a catadromous life cycle, with a single panmictic population that colonises continental Europe and northern Africa yet migrates 5000 to 9000 km to spawn in the Atlantic Ocean. It is unknown how this continental migration is organised so individual eels arrive in time for spawning with conspecifics. This meta‐analysis combined tracking data from 18 water bodies in freshwater and tran...
Spatial and temporal analysis of juvenile blacktip reef shark ( Carcharhinus melanopterus ) demographies identifies critical habitatsNARA Subscribed
Reef shark species have undergone sharp declines in recent decades, as they inhabit coastal areas, making them an easy target in fisheries (i.e., sharks are exploited globally for their fins, meat, and liver oil) and exposing them to other threats (e.g., being part of by‐catch, pollution, and climate change). Reef sharks play a critical role in coral reef ecosystems, where they control populations of smaller predators and herb...
A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery AnalysisNARA Subscribed
Candidate gene studies have identified genetic variants associated with clinical outcomes following aneurysmal subarachnoid haemorrhage (aSAH), but no genome-wide association studies have been performed to date. Here we report the results of the discovery phase of a two-stage genome-wide meta-analysis of outcome after aSAH. We identified 157 independent loci harbouring 756 genetic variants associated with outcome after aSAH (...
Incorporating ecology into gene drive modellingNARA Subscribed
Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into wild populations, represents a promising new tool in the fight against vector‐borne diseases, agricultural pests and invasive species. Due to the risks involved, gene drives have so far only been tested in laboratory settings while their population‐level behaviour is mainly studied using mathematical and computational models. The spread...
Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: ProtocolNARA Subscribed
Aneurysmal subarachnoid haemorrhage (aSAH) results in persistent clinical deficits which prevent survivors from returning to normal daily functioning. Only a small fraction of the variation in clinical outcome following aSAH is explained by known clinical, demographic and imaging variables; meaning additional unknown factors must play a key role in clinical outcome. There is a growing body of evidence that genetic variation is...
Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type allelesNARA Subscribed
Rapid evolutionary processes can produce drastically different outcomes when studied in panmictic population models vs. spatial models. One such process is gene drive, which describes the spread of “selfish” genetic elements through a population. Engineered gene drives are being considered for the suppression of disease vectors or invasive species. While laboratory experiments and modelling in panmictic populations have shown...
Understanding why different life history strategies respond differently to changes in environmental variability is necessary to be able to predict eco-evolutionary population responses to change. Marine megafauna display unusual combinations of life history traits. For example, rays, sharks and turtles are all long-lived, characteristic of slow life histories. However, turtles also have very high reproduction rates and juvenil...
Tetraspanin CD81 regulates HSV-1 infectionNARA Subscribed
EPMA-World Congress 2015NARA Subscribed