Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...

Soil microbiomes are critical for ecosystem functioning, yet the global influences of climate and agricultural practices on their diversity and structure remain incompletely characterized. Here we analyzed 1921 soil samples from 33 countries worldwide across diverse biomes to assess how climate gradients and agricultural inputs, including pesticides and fertilizers, shape prokaryotic and fungal communities. We found that micro...

The expansion of aquaculture and the rising cost of fishmeal have driven research into fish gut health and the replacement of marine-derived ingredients with alternative protein sources, within sustainable strategies aligned with the Blue Transformation. In this sense, the objective of this study was to evaluate the effect of including a functional ingredient based on hydrolyzed microalgae and grape marc extracts in feeds with...