Isabel Vara results 7
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Cortical volumetry and longitudinal cognitive changes in Parkinson’s disease: insights from the COPPADIS cohortNARA Subscribed
Cognitive decline is a major non-motor symptom in Parkinson’s disease (PD), often linked to brain atrophy. This study examines the relationship between cortical atrophy and age groups in predicting cognitive decline in PD over five years. 188 PD patients from the COPPADIS cohort were stratified by age: young (30–55 years, N = 47), middle-aged (56–65 years, N = 59), and older adults (66–75 years, N = 82). Baseline cortical volu...
Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cellsNARA Subscribed
We have investigated the effects of melatonin on major pathways related with cellular proliferation and energetic metabolism in pancreatic stellate cells. In the presence of melatonin (1 mM, 100 µM, 10 µM, or 1 µM), decreases in the phosphorylation of c-Jun N-terminal kinase and of p44/42 and an increase in the phosphorylation of p38 were observed. Cell viability dropped in the presence of melatonin. A rise in the phosphorylat...
EPMA-World Congress 2015NARA Subscribed
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