Isabelle Roland results 22
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Chronological age is a common and non-modifiable factor for chronic disease, but does not fully explain age-related changes. Biological clocks have been developed to explore biological aging mechanisms. They could help identify protective factors against accelerated aging and associated diseases. We aim to assess the association between reduced epigenetic or inflammatory aging and ideal cardiovascular health or cardiovascular...
HealthAge: evaluation of intrinsic capacity changes in humans, mice, and killifish to explore the biology of agingNARA Subscribed
HealthAge was devised by a conglomerate of research groups in Toulouse, France, with the combined goal of narrowing the lifespan-healthspan gap through novel translational bench-to-bedside research studies. HealthAge comprises the “INStitute for Prevention” “healthy aging” and “medicine Rejuvenative” (INSPIRE) human translational, outbred SWISS mice and African turquoise killifish (GRZ strain) cohorts in which aging is studied...
Appetite loss is a common clinical condition in older adulthood, but how this condition associates with biological aging remains unknown. The present study aims to examine the associations of biological aging markers with appetite loss in community-dwelling people aged 21 to 102 years. This retrospective case–control study used baseline data from the INSPIRE-T cohort in Toulouse, France. Each of the 49 cases with appetite loss...
Postglacial climate changes and rise of three ecotypes of harbour porpoises, P hocoena phocoena , in western P alearctic watersNARA Subscribed
Despite no obvious barriers to gene flow in the marine realm, environmental variation and ecological specializations can lead to genetic differentiation in highly mobile predators. Here, we investigated the genetic structure of the harbour porpoise over the entire species distribution range in western Palearctic waters. Combined analyses of 10 microsatellite loci and a 5085 base‐pair portion of the mitochondrial genome reveale...
Improving plant functional groups for dynamic models of biodiversity: at the crossroads between functional and community ecologyNARA Subscribed
The pace of on‐going climate change calls for reliable plant biodiversity scenarios. Traditional dynamic vegetation models use plant functional types that are summarized to such an extent that they become meaningless for biodiversity scenarios. Hybrid dynamic vegetation models of intermediate complexity (hybrid‐ DVM s) have recently been developed to address this issue. These models, at the crossroads between phenomenological...
LCA study of a plasma television deviceNARA Subscribed
We explore the role of lakes in carbon cycling and global climate, examine the mechanisms influencing carbon pools and transformations in lakes, and discuss how the metabolism of carbon in the inland waters is likely to change in response to climate. Furthermore, we project changes as global climate change in the abundance and spatial distribution of lakes in the biosphere, and we revise the estimate for the global extent of c...
Projected changes in mineral soil carbon of European croplands and grasslands, 1990–2080NARA Subscribed
We present the most comprehensive pan‐European assessment of future changes in cropland and grassland soil organic carbon (SOC) stocks to date, using a dedicated process‐based SOC model and state‐of‐the‐art databases of soil, climate change, land‐use change and technology change. Soil carbon change was calculated using the Rothamsted carbon model on a European 10 × 10′ grid using climate data from four global climate models im...
Attenuation of ultraviolet radiation in mountain lakes: Factors controlling the among‐ and within‐lake variabilityNARA Subscribed
High‐altitude lakes are exposed to high fluence rates of solar ultraviolet radiation (UVR; 29–400 nm) and contain low concentrations of dissolved organic carbon (DOC). While in most lowland lakes, DOC can be used to predict UV transparency with sufficient accuracy, current models fail to estimate UVR in clear alpine lakes. In these lakes, phytoplankton may contribute significantly to the UV attenuation either as particles or a...
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