Calsequestrin 2 (CASQ2) has emerged as a central sensor and modulator of calcium (Ca 2+ ) dynamics in sarcoplasmic reticulum (SR), influencing both health and disease. This review explores the molecular architecture and multifunctional roles of CASQ2, beginning with its domain organization and Ca 2+ -binding properties and detecting how its folding and supramolecular assembly modulate Ca 2+ storage and release within cardiac m...

Upper Cretaceous–Lower Paleogene successions along the southern Tethyan margin record the combined effects of global environmental perturbations, relative sea-level change, and regional tectonism. This study reconstructs paleoenvironmental and sequence-stratigraphic evolution across Maastrichtian–Ypresian strata in four Esh El-Mellaha sections, northern Eastern Desert, Egypt, using integrated lithostratigraphy, microfacies, be...

The usage of potassium bromate (PB) in various consumer items and food and chemical industries poses a serious health risk like nephrotoxicity along with other toxic abuses. The compound elicits mild to severe toxic insults in a dose-dependent way in vivo and can even trigger carcinogenesis if exposed for long. This investigation ascertains the protective effect of naringenin (NIR), a polyphenol, in the PB-challenged rats. The...

Understanding the spatial variability of crop drought sensitivity is critical for improving agricultural resilience in the face of climate change. This study presents a station-level analysis of meteorological and yield data across Iowa from 1998 to 2022 to investigate the relationship between multiple drought indices and detrended yields of corn and soybean. Eleven drought indicators were selected to capture both short-term a...