Human in vitro liver tissue models have evolved to maintain hallmarks of hepatocellular function for extended periods with potential to model aspects of cholestasis for drug and chemical safety applications. Microphysiological systems (MPS) have been suggested as promising new approaches to model liver physiology and predict chemical-induced cholestasis in humans. This study comprehensively compared both basal function and tox...

On February 3, 2023, a train carrying hazardous chemicals derailed in East Palestine, Ohio. Initial mobile air monitoring in mid-February 2023 revealed unique spatiotemporal patterns for a range of volatile organic compounds (VOCs). To determine long-term impacts on air quality, two follow up mobile air monitoring campaigns were carried out in March and April 2023 on public roadways using a proton transfer reaction time-of-fli...