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Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochleaNARA Subscribed
Pathogenic variation of SLC26A 4 gene causes both Pendred syndrome (PDS) and non-syndromic enlarged vestibular aqueduct (NSEVA/DFNB4), two autosomal recessive disorders. The former accounts for approximately 6% of human genetic hearing loss, making it the second most common form of syndromic deafness after Usher syndrome, while the latter is the most common radiological malformation associated with childhood sensorineural hear...
Age is important for studying population dynamics, but it is difficult to obtain reasonably accurate age estimates and associated uncertainty of free‐ranging individuals, especially for cetaceans. We developed a protocol for deriving probabilistic age estimates using information commonly curated in marine mammal photo‐identification catalogs and applied the approach to 81 biopsy‐sampled and genetically sexed false killer whale...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Smallmouth buffalo (Ictiobus bubalus Rafinesque) population trends and demographics in the Upper Mississippi River SystemNARA Subscribed
Smallmouth buffalo ( Ictiobus bubalus Rafinesque) are a large-bodied fish highly valued and commercially exploited across most of their range. Despite this, relatively little is known of their population demographics compared to other exploited species. To fill these knowledge gaps, we analyzed two independent long-term datasets (30 and 57 years, respectively) and population demographic data (age structure, growth, mortality,...
Multi-modal MRI of hippocampal morphometry and connectivity after pediatric severe TBINARA Subscribed
This investigation explores memory performance using the California Verbal Learning Test in relation to morphometric and connectivity measures of the memory network in severe traumatic brain injury. Twenty-two adolescents with severe traumatic brain injury were recruited for multimodal MRI scanning 1–2 years post-injury at 13 participating sites. Analyses included hippocampal volume derived from anatomical T1-weighted imaging,...
Isopropyl alcohol inhalation versus 5-HT3 antagonists for treatment of nausea: a meta-analysis of randomised controlled trialsNARA Subscribed
Purpose Nausea is a common and unpleasant sensation for which current therapies such as serotonin (5-HT 3 ) antagonists are often ineffective, while also conferring a risk of potential adverse events. Isopropyl alcohol (IPA) has been proposed as a treatment for nausea. We aimed to compare IPA with 5-HT 3 antagonists for the treatment of nausea across all clinical settings. Methods MEDLINE, EMBASE, PubMed, CENTRAL and CINAHL we...
Advocates, practitioners and policy‐makers continue to use and advocate for marine protected areas (MPAs) to meet global ocean protection targets. Yet many of the worlds MPAs, and especially no‐take MPAs, are plagued by poaching and ineffective governance. Using a global dataset on coral reefs as an example, we quantify the potential ecological gains of governing MPAs to increase compliance, which we call the ‘compliance gap’....
From reflection diaries to practical guidance for transdisciplinary research: learnings from a Kenyan air pollution projectNARA Subscribed
Transdisciplinary research (TDR) approaches have been cited as essential for overcoming the intractable sustainability challenges that the world is currently facing, including air pollution, water management and climate change. However, such approaches can be difficult to undertake in practice and can consequently fail to add value. Therefore, examples of what works in practice (and what does not) are helpful to guide future r...
The Bolometric Bond Albedo of EnceladusNARA Subscribed
Purpose Following resistance exercise, uncertainty exists as to whether the regular application of cold water immersion attenuates lean muscle mass increases in athletes. The effects of repeated post-resistance exercise cold versus hot water immersion on body composition and neuromuscular jump performance responses in athletes were investigated. Methods Male, academy Super Rugby players ( n = 18, 19.9 ± 1.5 y, 1.85 ± 0.06 m, 9...
Effect of inoculation with prion dilutions within the dynamic range of ELISA absorbance on prion incubation periodNARA Subscribed
This study examines the effect of various infectious prion titers within the dynamic range as measured by ELISA on incubation period. We inoculated ovinized transgenic mice with seven decreasing dilutions of a fast-incubating scrapie strain. The highest inoculum group was a 20% w/v brain homogenate from a sheep with scrapie. The subsequent six inoculum dilutions ranged from the highest ELISA optical density reading of 4.000 to...
Small‐scale fisheries account for 90% of global fishers and 40% of the global catch. Effectively managing small‐scale fisheries is, therefore, crucial to progressing the United Nations Sustainable Development Goals (SDGs). Co‐management and community‐based fisheries management are widely considered the most appropriate forms of governance for many small‐scale fisheries. We outlined relationships between small‐scale fisheries c...
Unveiling buried aeolian landscapes: reconstructing a late Holocene dune environment using 3D ground‐penetrating radarNARA Subscribed
Across the UK, sandy beaches and dunes protect coastal infrastructure from waves and extreme water levels during large‐scale storms, while providing important habitats and recreational opportunities. Understanding their long‐term evolution is vital in managing their condition in a changing climate. Recently, ground‐penetrating radar (GPR) methods have grown in popularity in geomorphological applications, yielding centimetre‐sc...
Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke ModelNARA Subscribed
Magnetic resonance imaging (MRI) is a clinically relevant non-invasive imaging tool commonly utilized to assess stroke progression in real time. This study investigated the utility of MRI as a predictive measure of clinical and functional outcomes when a stroke intervention is withheld or provided, in order to identify biomarkers for stroke functional outcome under these conditions. Fifteen MRI and ninety functional parameters...