The latest hypothesis regarding the source of enhanced neural activation from resistance training is the reticulospinal rather than the corticospinal tract, based on invasive animal and emerging human data. The present study employed a six-week isometric resistance training intervention in a randomized controlled design to address this knowledge gap. Thirty-nine healthy, untrained males (age ~23 y, sustained contraction group...

AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...

Global conservation maps often overlook community lands, impacting decision-making and reducing local agency. We focus on the high-profile and regionally important case of Massaha’s ancestral territory (Ibola Dja Bana Ba Massaha). In Gabon, the forest is largely gazetted into logging concessions and described as an Eden-like wilderness despite long-term human presence. We compare Massaha’s biocultural maps to global, colonial,...

Motivation The database initiated by the Mountain Invasion Research Network (MIREN) is one of the few globally implemented standardized vegetation surveys in mountains. The focus is on collecting plant species occurrences at 5‐year intervals along and adjacent to mountain roads spanning elevational gradients, with the goal of providing critical information about the ongoing spread of non‐native plants and the potential impacts...

The fast‐slow continuum is a key axis of variation in life history strategies capturing the evolutionary trade‐off between allocation in lifespan versus reproduction. It has been suggested that social behaviour, and therefore network structure, may vary across this continuum, but formal theory remains scarce. We develop a mathematical model to examine how the rate of demographic replacement may influence emergent social networ...

Lynch syndrome, the most common hereditary cancer syndrome, is caused by germline pathogenic variants in DNA mismatch repair (MMR) genes. Identifying complex or structural MMR gene pathogenic variants can be challenging with short-read sequencing resulting in patients with unexplained MMR-deficient tumours. In this study, we report multiple members of a family who developed MSH2-deficient tumours where clinical multi-gene pane...

Heat stress can disrupt coordinated regulatory processes underpinning normal development, resulting in embryonic malformation and inviability. Embryonic buffering against thermal challenge may therefore play a crucial role in individual survival and population resilience under heat stress. Yet, the molecular mechanisms underpinning embryonic defence against ecologically‐meaningful heat stresses remain poorly understood. We inv...

Mauna Loa volcano erupted on November 27, 2022, after 38 years of quiescence, marking the first eruption of the world’s largest active volcano since 1984. Precursory activity was characterized by escalating seismicity and ground deformation, with increased unrest beginning in mid-September 2022. At 22:24 HST, tilt and seismic alarms alerted Hawaiian Volcano Observatory staff to escalating activity, signaling an imminent erupti...