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Dementia affects over 55 million people worldwide, with Alzheimer’s disease (AD) comprising most cases. Because curative therapies remain unavailable, there is an urgent need for prevention strategies that target modifiable risk factors. Behavioral interventions—particularly sleep improvement and physical activity—can independently benefit cognition, brain function, and cardiometabolic health, yet their combined (potentially s...
Biochemical and structural characterization of beta-carbonic anhydrase from the parasite Trichomonas vaginalisNARA Subscribed
Trichomonas vaginalis is a unicellular parasite and responsible for one of the most common sexually transmittable infections worldwide, trichomoniasis. Carbonic anhydrases (CAs) are enzymes found in all lifeforms and are known to play a vital role in many biochemical processes in organisms including the maintenance of acid–base homeostasis. To date, eight evolutionarily divergent but functionally convergent forms of CAs (α, β,...
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