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Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesisNARA Subscribed
Chronic inorganic arsenic (iAs) exposure affects > 220 million people worldwide and skin cancer is a hallmark of long-term iAs exposure. Limited information exists regarding arsenic methylation by human keratinocytes and how methylation influences skin carcinogenesis. Inorganic arsenite (iAs III ) and its methylated metabolites disrupt diverse zinc finger proteins, leading to differential toxicity patterns. We examined arsenic...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
Marine primary production, converting approximately 50 Gt of inorganic carbon into organic carbon per year, is an important component of the global carbon cycle, and a major determinant of past, present and future climate. Large-scale, long-term estimates of marine primary production rely primarily on two types of models: satellite-based models that make extensive use of remote-sensing data, and ecosystem models providing nume...
Literature reviews have become increasingly prominent in scientific discourse; however, few have critically examined the geographic distribution of research, particularly in the field of biometeorology, where studies remain disproportionately concentrated in the Global North. Building on previous regional reviews and special issues, this paper critically examines geographic disparities in publication trends, authorship, and me...
In the last 2 decades, UK research institutes have led a wide range of developments in marine data assimilation (MDA), covering areas from operational applications in physics and biogeochemistry to fundamental theory. We highlight the emergence of strong collaboration in the UK MDA community over this period and the increasing unification of its tools. We focus on identifying the MDA stakeholder community and current/future ar...
The primary aim of the present study was to reveal the major differences between benzene-degrading bacterial communities evolve under aerobic versus microaerobic conditions and to reveal the diversity of those bacteria, which can relatively quickly degrade benzene even under microaerobic conditions. For this, parallel aerobic and microaerobic microcosms were set up by using groundwater sediment of a BTEX-contaminated site and...