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Acute COVID-19 is associated with altered CD8 T-cells indicative of impaired ability to control Epstein–Barr virus reactivationNARA Subscribed
Increasing evidence suggests that reactivation of latent EBV in patients with COVID-19 may be linked to the development of post-acute sequelae of COVID-19, colloquially known as Long COVID. However, the reason for this co-occurrence of primary infection and reactivation of latent viruses remains elusive. During the first wave of COVID-19, we assessed all major immune cell populations by flow cytometry in a cohort of 61 patient...
If the target of a goal-directed arm movement is suddenly displaced, the movement is quickly adjusted accordingly. There are situations in which grouping gives the impression that many items have been displaced, although the change that determines the direction of the perceived displacement occurs far from the target. When a single item disappears from one end of a row of items just when an item appears at the other end, it lo...
Intercepting moving targets: does the visuomotor latency depend on whether one taps on the target or slides through it?NARA Subscribed
When trying to intercept a moving target, one’s movements are continuously adjusted to match the latest information about the target’s position. Many target characteristics influence the latency of such adjustments. Does the kind of movement that is being made also influence this visuomotor latency? Since there are reasons to suspect that it might, we compared the latency of responses to sudden jumps in moving targets’ positio...
We previously found that arm movements towards a jittering target are constantly guided by the latest target position: the responses to target displacements became more vigorous as the movement proceeded, as required for the movement to reach the latest position smoothly within the remaining time. Here we examine whether this behaviour was a consequence of how that experiment was designed. We compared the vigour of adjustments...
Evaluating predictors of kinase activity of STK11 variants identified in primary human non-small cell lung cancersNARA Subscribed
Critical evaluation of computational tools for predicting variant effects is important considering their increased use in disease diagnosis and driving molecular discoveries. In the sixth edition of the Critical Assessment of Genome Interpretation (CAGI) challenge, a dataset of 28 STK11 rare variants (27 missense, 1 single amino acid deletion), identified in primary non-small cell lung cancer biopsies, was experimentally assay...
High-risk human papillomaviruses are well-established drivers of several cancer types including cervical, head and neck, penile as well as anal cancers. While the E6 and E7 viral oncoproteins have proven to be critical for malignant transformation, evidence is also beginning to emerge suggesting that both host pathways and additional viral genes may also be pivotal for malignant transformation. Here, we focus on the role of ho...
Phylosymbiosis and Elevated Cancer Risk in Genetically Depauperate Channel Island FoxesNARA Subscribed
Examination of the host‐associated microbiome in wildlife can provide critical insights into the eco‐evolutionary factors driving species diversification and response to disease. This is particularly relevant for isolated populations lacking genomic variation, a phenomenon that is increasingly common as human activities create habitat ‘islands’ for wildlife. Here, we characterised the gut and otic microbial communities of one...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed
People generally look at a target when they want to reach for it. Doing so presumably helps them continuously update their judgments about the target’s position and motion. But not looking at their hand does not prevent people from updating judgments about its position on the basis of visual information, because people do respond to experimental perturbations of visual information about the position of their hand. Here, we stu...
People rely upon sensory information in the environment to guide their actions. Ongoing goal-directed arm movements are constantly adjusted to the latest estimate of both the target and hand’s positions. Does the continuous guidance of ongoing arm movements also consider the latest visual information of the position of obstacles in the surrounding? To find out, we asked participants to slide their finger across a screen to int...
How the timing of visual feedback influences goal-directed arm movements: delays and presentation ratesNARA Subscribed
Visual feedback normally helps guide movements to their goal. When moving one’s hand, such guidance has to deal with a sensorimotor delay of about 100 ms. When moving a cursor, it also has to deal with a delay of tens of milliseconds that arises between the hand moving the mouse and the cursor moving on the screen. Moreover, the cursor is presented at a certain rate, so only positions corresponding with the position of the mou...
Far UV-C radiation: An emerging tool for pandemic controlNARA Subscribed
New Co-Editors-in-Chief for the Journal of PaleolimnologyNARA Subscribed
Ceruminous gland tumours are highly prevalent in the ear canals of Santa Catalina Island foxes ( Urocyon littoralis catalinae ). Previous work suggests that tumours may result from a combination of ectoparasites, disruption of the host‐associated microbiome, and host immunopathology. More specifically, ear mite infection has been associated with broad‐scale microbial dysbiosis marked by secondary bacterial infection with the o...