Young blood plasma is known to confer beneficial effects on various organs in mice and rats. However, it was not known whether plasma from young adult pigs rejuvenates old rat tissues at the epigenetic level; whether it alters the epigenetic clock, which is a highly accurate molecular biomarker of aging. To address this question, we developed and validated six different epigenetic clocks for rat tissues that are based on DNA m...

DNA methylation-based biomarkers of aging have been developed for many mammals but not yet for the vervet monkey ( Chlorocebus sabaeus ), which is a valuable non-human primate model for biomedical studies. We generated novel DNA methylation data from vervet cerebral cortex, blood, and liver using highly conserved mammalian CpGs represented on a custom array (HorvathMammalMethylChip40). We present six DNA methylation-based esti...

DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age, epigenetic clocks, for many species. Using a custom methylation array, we generated DNA methylation data from n = 238 porcine tissues including blood, bladder, frontal cortex, kidney, liver, and lung, from domestic pigs ( Sus scrofa domesticus ) and minipigs (Wisconsin Miniature Swine™). Samples used in this study originated from...

Accurate identification of individual ages within wild bottlenose dolphins ( Tursiops truncatus ) is critical for determining population health and the development of population management strategies. As such, we analyzed DNA methylation (DNAm) patterns by applying a custom methylation array (HorvathMammalMethyl40) to both blood ( n = 140) and skin samples ( n = 87) from known age or approximate age (0–57 years) bottlenose dol...

Observational analyses of changing climate extremes over the West Africa region have been limited by the availability of long and high‐quality datasets. To help address this gap, a climate extremes indices workshop was held in the Gambia in December 2011 with participants from 14 West African countries. The resulting analysis utilized 15 annual indices derived from observed daily temperatures and 10 annual indices derived from...

Up‐to‐date regional and local assessments of changing climate extremes are important to allow countries to make informed decisions on mitigation and adaptation strategies, and to put these changes into a global context. A workshop for countries from the Indo‐Pacific region has brought together daily observations from 13 countries for an analysis of climate extremes between 1971 and 2005. This paper makes use of the workshop ou...