Endoplasmic reticulum aminopeptidases (ERAP) facilitate antigen presentation. Variation in ERAP1 and ERAP2 genes underwent selection during the Black Death and impact autoimmune disease susceptibility. We assess the burden of functionally impactful variants present in ERAP1 and ERAP2 in 2 cohorts of patients diagnosed with inflammatory bowel disease (IBD; Crohn’s disease (CD) or ulcerative colitis (UC)). We analysed the Southa...

Acute respiratory exacerbations in bronchiectasis are important as they impair quality of life and are associated with accelerated lung function decline. Yet, no validated methods exist to identify children at increased risk of exacerbations. We therefore determined if peripheral blood gene expression (GE) signatures can identify those at risk of an impending exacerbation. Thirty-one children with bronchiectasis had RNA extrac...

Based on daily rainfall data from 252 national meteorological stations in the Haihe River Basin of China during 1961–2023, rainstorm events were divided, and four characteristic variables representing the hazard index of rainstorms were statistically analyzed, including total number of rainstorm days ( I day ), cumulative rainfall ( I pre ), average daily rainfall ( I 24pre ), and maximum duration days ( I dur ). Combined with...