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A primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principlesNARA Subscribed
Indigenous tribal communities are frequently underserved by genomic medicine because they are under-represented in research, often live in remote locations and have ethical and cultural perspectives that vary from westernised standpoints. The Rakeiora platform, a permissioning and analytical environment that incorporates Māori perspectives and ethical frameworks on how precision medicine research is best conducted was used to...
High Resprouting of Plants Within 16 Months of Wildfire in a Dry Grassland in Aotearoa New ZealandNARA Subscribed
Wildfires are projected to increase in severity and frequency in dryland ecosystems due to climate change. To predict how plant communities will respond to these changes in wildfire patterns, it is vital to understand how plants establish following fire; such knowledge is limited in Aotearoa New Zealand. Individual plants regenerate after fire by resprouting or germinating from seeds. We aimed to quantify short‐term community...
Leaf Dry Matter Content Is Phylogenetically Conserved and Related to Environmental Conditions, Especially Wildfire ActivityNARA Subscribed
Leaf dry matter content (LDMC) is an important determinant of plant flammability. Investigating global patterns of LDMC could provide insights into worldwide plant flammability patterns, informing wildfire management. We characterised global patterns of LDMC across 4074 species from 216 families, revealing that phylogenetic and environmental constraints influence LDMC. LDMC varied across growth forms and taxonomic groups, disp...
Damage to tropical forests caused by cyclones is driven by wind speed but mediated by topographical exposure and tree characteristicsNARA Subscribed
Each year, an average of 45 tropical cyclones affect coastal areas and potentially impact forests. The proportion of the most intense cyclones has increased over the past four decades and is predicted to continue to do so. Yet, it remains uncertain how topographical exposure and tree characteristics can mediate the damage caused by increasing wind speed. Here, we compiled empirical data on the damage caused by 11 cyclones occu...
Rationale Chronic cannabis use is associated with impaired cognitive function. Evidence indicates cannabidiol (CBD) might be beneficial for treating cannabis use disorder. CBD may also have pro-cognitive effects; however, its effect on cognition in people with cannabis use disorder is currently unclear. Objectives We aimed to assess whether a 4-week CBD treatment impacted cognitive function. We hypothesised that CBD treatment...
Monitoring how populations respond to sustained conservation measures is essential to detect changes in their population status and determine the effectiveness of any interventions. In the case of sea turtles, their populations are difficult to assess because of their complicated life histories. Ground-derived clutch counts are most often used as an index of population size for sea turtles; however, data are often incomplete w...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Low dispersal and ploidy differences in a grass maintain photosynthetic diversity despite gene flow and habitat overlapNARA Subscribed
Geographical isolation facilitates the emergence of distinct phenotypes within a single species, but reproductive barriers or selection are needed to maintain the polymorphism after secondary contact. Here, we explore the processes that maintain intraspecific variation of C 4 photosynthesis, a complex trait that results from the combined action of multiple genes. The grass Alloteropsis semialata includes C 4 and non‐C 4 popula...
Müllerian mimicry of a quantitative trait despite contrasting levels of genomic divergence and selectionNARA Subscribed
Hybrid zones, where distinct populations meet and interbreed, give insight into how differences between populations are maintained despite gene flow. Studying clines in genetic loci and adaptive traits across hybrid zones is a powerful method for understanding how selection drives differentiation within a single species, but can also be used to compare parallel divergence in different species responding to a common selective p...