J. Duncan results 417
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Piscirickettsiosis in Farmed Turbot, Scophthalmus maximusNARA Subscribed
Piscirickettsia salmonis is a well‐established intracellular pathogen of farmed Atlantic salmon around the world. The bacterium has also been detected from a number of other hosts including lumpfish ( Cyclopterus lumpus ), seabass ( Dicentrarchus labrax ) and rainbow trout ( Oncorhynchus mykiss ) . In February 2025, increased mortality was observed in a population of turbot, Scophthalmus maximus , farmed in Norway. Macroscopic...
A somatosensory fovea in the fingertips of the Surinam toadNARA Subscribed
The Surinam toad ( Pipa pipa ) is a fully aquatic, tongueless pipid frog that captures prey using rapid suction feeding coordinated by the forelimbs. The digit tips bear distinctive lobed structures whose function has been unknown. Here we characterize the morphology, mechanical sensitivity, peripheral innervation, central representation, and behavioral function of these digit tip lobes using scanning electron microscopy, von...
Endangered species laws and the inclusion of Indigenous knowledges and sciences in risk assessmentsNARA Subscribed
Indigenous Peoples actively manage or have tenure rights over lands where many rare and valued species occur. To meet national and global conservation targets, it is important to meaningfully consider Indigenous knowledges and rights in endangered species laws. We examined whether the Canadian Species at Risk Act (SARA) has upheld its commitment to consider Indigenous knowledges in decisions pertaining to endangered species as...
Quantifying the Viscoelastic Properties of Pancreatic Tissue: A Comparative Study of Human, Porcine and Engineered HydrogelNARA Subscribed
Pancreatoduodenectomy (PD) is among the most complex abdominal procedures, with a leak from the pancreatic anastomosis (postoperative pancreatic fistula, POPF) continuing to be a major source of morbidity and mortality. The mechanical characteristics of the pancreas, particularly tissue texture, are closely linked to POPF risk, yet remain poorly defined, limiting the accuracy of currently available training models. This study...
Some invasive species threaten native species because they possess traits to which natives are evolutionarily naïve. In Australia, many predators have been severely impacted by the introduction of cane toads, which produce toxins that native species have never encountered. Torresian crows, however, have been observed consuming cane toads safely by avoiding their toxin glands, suggesting learned behavioural adaptations. To inve...
The critically endangered geophyte Gladiolus aureus threatened by a wilt disease associated with Fusarium libertatisNARA Subscribed
Gladiolus aureus is a geophyte species endemic to the South African Cape Peninsula. Pressures including land-use change and invasion by alien plants have caused severe population declines, leading to its classification as Critically Endangered (CR). Kirstenbosch National Botanical Garden (NBG) maintains the largest ex situ collection of this species. During plant health surveys conducted as part of a sentinel plant research pr...
Bridging science and action: the Western Water Assessment’s evolution in the provision of climate informationNARA Subscribed
Universities are increasingly becoming centers for activities that bridge the gap between weather and climate information. These activities integrate emerging research with science-informed decision-making to contribute to the development of official climate services. Yet there is relatively little literature describing how they balance the competing demands of stakeholder engagement, academic incentives, and the need for acti...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitisNARA Subscribed
Fungal keratitis (FK), caused by fungi like Aspergillus , Fusarium , and Candida , accounts for 20–60% of microbial keratitis cases and over 1 million visual impairments annually. Voriconazole (VOR) is effective against FK, but its eye drop formulations suffer from poor bioavailability, while intrastromal injections are invasive and carry risks. This study aimed to address these challenges by formulating a VOR nanosuspension (...
Single-cell transcriptomics of acetaminophen-induced responses in human 2D and 3D liver microtissuesNARA Subscribed
Drug-induced liver injury remains a major obstacle in pharmaceutical development and a leading cause of acute liver failure, underscoring the need for predictive and human-relevant in vitro models. Acetaminophen, a widely used analgesic with well-characterized dose-dependent hepatotoxicity, serves as a benchmark compound for evaluating liver toxicity mechanisms. Here, we applied single cell RNA sequencing to characterize cellu...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...