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Alzheimer’s disease (AD) is the leading cause of dementia and evidence suggests that alcohol, the most commonly used addictive substance, may increase AD risk. Locus coeruleus (LC) neurons are the primary source of norepinephrine in the brain and these neurons degenerate early in AD. In rodent models, lesioning the LC increases amyloid beta (Aβ) pathology suggesting that LC integrity and norepinephrine signaling obstruct Aβ pa...
Multiple sclerosis (MS) is a neurological disorder characterized by damage to the myelin sheaths surrounding axons in the central nervous system, causing decreased axonal signal transmission and disability in people with MS. Epstein-Barr virus (EBV) infection and vitamin D deficiency have been put forward as causal factors for the development of MS, but their effects have not been conclusively linked to the disruption of myeli...
Land use, hydroclimate and damming influence organic carbon sedimentation in a flood pulse wetland, MalaysiaNARA Subscribed
Water bodies located in floodplains and tropical forests are known to be important carbon stores, but many are subjected to intensive pressures from damming, land use and climate changes. Sedimentary records preserve long‐term archives for understanding how such changes affect the quantity and quality of carbon stores. We analysed sediment cores from seven sites across a flood‐pulse multi‐basin wetland, Tasik Chini in Peninsul...