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Military free-fall parachute operations subject Service Members to sudden mechanical loads during tether snatch and canopy opening, creating a high risk of musculoskeletal injury. Traditional video-based motion capture is impractical in these environments, limiting the ability to estimate joint-level kinematics in vivo. This study evaluated the feasibility of integrating wearable inertial measurement units (IMUs) with musculos...
Sporecasting Biogeography Across Scales: Continental Patterns and Local Constraints on Macrofungal DispersalNARA Subscribed
Understanding how aerial fungal diversity varies across space, habitat, and disturbance is key to linking local‐scale sporocarp (fruiting body) reproduction with continental‐scale biogeography. In this study, we combined passive spore trap metabarcoding with macrofungal sporocarp records from 31 plots in eight sites across North America to quantify how site, habitat, and fire history shape aerial macrofungal communities. From...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
HABS-BLOCKS© Reduced Harmful Algal Bloom Activity in an in-Lake Limno-Corral Mesocosm Case Study at Grand Lake St. Marys, Ohio (USA)NARA Subscribed
HABS-BLOCKS© infused with glucose have been shown to reduce cyanobacterial populations and microcystin (MC) concentrations in laboratory mesocosm studies. An in situ limno-corral (LC) mesocosm study of HABS-BLOCKS© was conducted for two weeks during the 2025 algal bloom in Grand Lake St. Marys (GLSM) (Ohio, USA). Thirty HABS-BLOCKS© or Dummy HABS-BLOCKS© (contain no glucose) were added to three treated or three control LCs, re...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responsesNARA Subscribed
Toll-like receptors (TLRs) are the best characterized family of Pattern Recognition Receptor-targeting adjuvants. Activation of TLR7/8 in particular, enhances antigen presentation by dendritic cells and macrophages, boosting Th1-mediated adaptive immune responses. However, poor pharmacokinetics and systemic toxicity of some TLR7/8 ligands hinder their clinical translation. Lipidation and incorporation of TLR7/8 ligands into li...
Patterns of divergence and speciation on islands have long been of interest in the broader study of evolution. Hawaiʻi’s endemic Kamehameha butterfly ( Vanessa tameamea ) is experiencing population decline, but because of its high vagility and assumed genetic homogeneity as a species, its population structure has not been investigated. To evaluate V. tameamea genetic variation across the Hawaiian Islands, we assembled a refere...
Wetlands are becoming increasingly used as tools to help watersheds mitigate nutrient runoff as part of efforts to reduce the frequency of harmful algal blooms. Wetland restoration is needed given that the majority of these habitats have been lost to development/draining efforts on a global scale over the past few centuries. The objective of this study was to monitor nutrient reductions achieved with the restored (constructed...
Within-farm spatiotemporal variability impacts carrot yield and quality more than preceding cover crop on a Canadian organic farmNARA Subscribed
Carrot ( Daucus carota ) is an important crop grown in Canada and globally. Fresh market carrots have strict cosmetic requirements to command full value at “Grade A” and are frequently downgraded for irregular shape, size, or pest damage. Organic farming presents challenges for nutrient management, soil health and pest control, which may be mitigated with cover cropping. A 3-year field experiment was conducted on a commercial...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...