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Genetic studies have differentiated three subspecies of humpback whales: Megaptera novaeangliae novaeangliae in the North Atlantic, M. n. australis in the Southern Hemisphere and M. n. kuzira in the North Pacific. However, these analyses did not include samples from the Arabian Sea humpback whale population (ASHW). Historic, behavioural, and previously published genetic data suggested that ASHWs are a discrete, isolated and re...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Assessing the temporal clustering of coastal storm tide hazards under natural variability in a near 500-year model runNARA Subscribed
The temporal clustering of storms can present successive natural hazards for coastal areas in the form of extreme sea levels, storm surges and waves. Studies have investigated the prevalence of the temporal clustering of such hazards but are hindered by the rarity of the phenomena combined with short records and a lack of data availability around the coastline. This has made it difficult to determine if the levels of clusterin...
Octocorals have increased in abundance on many Caribbean coral reefs, and at some sites, “octocoral forest” may be a better community descriptor than “coral reef.” Implicit to the concept of a forest is that structural elements, i.e., trees, colonies, etc., alter the environment in ways that affect the structural elements themselves and the organisms that inhabit the forest. At what density do the structural elements create th...
Shared and Divergent Processes Linked to Monocot Diversity Across the Mediterranean Climate RegionsNARA Subscribed
Aim The five Mediterranean regions of the globe are plant biodiversity hotspots, and there has not been a comparative analytical framework examining correlates of diversity across these regions. Of Mediterranean plant diversity, monocots constitute a considerable proportion that has yet to be explicitly examined comparatively. We combine phylogenetic, spatial biodiversity and environmental data to test if shared or divergent p...
Accurately characterizing white matter (WM) microstructure is critical for understanding neurodegenerative diseases such as semantic dementia (SD). Regionally constrained techniques like tract-based spatial statistics (TBSS) rely on diffusion-tensor imaging (DTI) and assume a single fiber population per voxel, limiting their sensitivity to complex architecture. Fixel-based analysis (FBA) overcomes these constraints by resolvin...