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Marine climate variability and change in the Torres StraitNARA Subscribed
Relative importance of climate versus socio-environmental development changes to 2050 in rural coastal Bangladesh—a system analysisNARA Subscribed
Climate change and development are having a profound influence on the integrity of coastal Bangladesh’s people, economy and ecology with climate change widely considered the dominant driver. Our bespoke integrated assessment model (IAM) simulates these changes for rural areas by coupling physical models with economic models, considering shocks like cyclone landfalls, and utilising substantial primary/secondary datasets and sta...
The lastreopsid ferns currently comprise four genera, with two of them, Lastreopsis and Parapolystichum , poorly delimited morphologically. Attribution of species to Lastreopsis or Parapolystichum has principally been by phylogenetic analysis of chloroplast DNA sequences. The last of the Australasian species of Lastreopsis to have its phylogenetic placement investigated is Lastreopsis nephrodioides , endemic to Lord Howe Islan...
Evaluation of physical and chemical modifications to drug reservoirs for stimuli-responsive microneedlesNARA Subscribed
Hydrogel-forming microneedle (MN) arrays are minimally-invasive devices that can penetrate the stratum corneum , the main barrier to topical drug application, without causing pain. However, drug delivery using hydrogel-forming MN arrays tends to be relatively slow compared to rapid drug delivery using conventional needles and syringes. Therefore, in this work, for the first time, different physical and chemical delivery enhanc...
Genetic diversity is the foundation of biodiversity, and preserving it is therefore fundamental to conservation practice. However, global conservation efforts face significant challenges integrating genetic and genomic approaches into applied management and policy. As collaborative partnerships are increasingly recognized as key components of successful conservation efforts, we explore their role and relevance in the Australia...
Purpose Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in the paediatric population is often hindered by poor adherence. Currently, two long-acting (LA) intramuscular injectable nanosuspensions of rilpivirine (RPV) and cabotegravir (CAB) are in clinical development for paediatric populations. However, administration requires access to healthcare resources, is pai...
Increasing shares of microfibers are being detected in environmental samples and a closer look to identify the risk associated with them using ecologically relevant endpoints, especially at sensitive early life stages, is needed. To assess exposure hazards, we used rope samples representative of fiber types ubiquitous in coastal systems, where microfibers are often the most common debris type found in the water column. To comp...
Designing a unique feedback mechanism for hydrogel-forming microneedle array patches: a concept studyNARA Subscribed
Although microneedle array patch (MAP) technology is reaching ever closer to regulatory approval, it remains imperative that approaches to further improve patient acceptance are still explored. Addressing this perception, a water-filled reservoir was incorporated into a hydrogel-forming MAP system to provide a novel feedback mechanism. To confirm successful MAP skin insertion, the end user would both hear and feel the rupture...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Wrestling with the complexity of evaluation for organizations at the boundary of science, policy, and practiceNARA Subscribed
Boundary organizations are situated between science, policy, and practice and have a goal of supporting communication and collaboration among these sectors. They have been promoted as a way to improve the effectiveness of conservation efforts by building stronger relationships between scientists, policy makers, industry, and practitioners (Cook et al. 2013). Although their promise has been discussed in theory, the work of and...