Gene-based therapies are being developed for retinal diseases, including RS1- related X-linked retinoschisis. Therefore it is essential to determine which variants are pathogenic and which are benign when enrolling patients. The Clinical Genome Resource (ClinGen) X-Linked Inherited Retinal Diseases (XLRD) Variant Curation Expert Panel (VCEP) brings together clinician scientists, molecular biologists, and geneticists to apply t...

We have attempted to re-establish bay scallops to the Virginia, U.S.A. coastal bays and document the dynamics of the restoration effort. Bay scallops ( Argopecten irradians ) once flourished in the eelgrass ( Zostera marina ) of the Virginia coastal bays. Eelgrass wasting disease led to declines, and both eelgrass and scallops were completely lost after a 1933 hurricane. The Virginia Institute of Marine Science (VIMS) led a su...

Summertime temperature extremes exert profound impacts on human health, ecosystems, and infrastructure, yet their characteristics and drivers remain poorly quantified in New Zealand, in part due to the country's complex topography and multiple climate regimes. Using high‐quality temperature observations from 30 weather stations spanning 1980–2022, this study examines the capability of a commonly used global reanalysis product,...

This study was conducted to determine how irrigation alters the effects of biochar on soil health parameters in a coarse texture soil for two consecutive growing seasons. Surface soil (0–15 cm) samples from a split-plot randomized block design (main plots, unirrigated and irrigated; subplots, 0 and 11.2 Mg ha − 1 biochar) taken after soybean ( Glycine max ) harvest in 2022 and 2023 were analyzed for electrical conductivity, pH...

Early detection through mammographic screening plays a central role in improving breast cancer outcomes, with diagnostic accuracy relying heavily on radiologist performance. While experience and case volume are recognised contributors to accuracy, the specific effect of weekly mammogram reading hours (HPW) remains unclear. This study examined the relationship between HPW and diagnostic performance among BreastScreen (BS) radio...

Victoria Cave, north Yorkshire, England, contains a long sequence of Pleistocene clastic sediments and calcite flowstones. Earlier work, using U–Th dating, established that the flowstone units formed in interglacial stages corresponding to Marine Isotope Stages (MIS) 13, 11, 9, 7 and 5. The intervening laminated sediments were therefore assigned to glacial stages (MIS 12, 10, 6 and 2) and regarded as rhythmites that settled fr...

Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or endurance exercise performance. The reduced form of CoQ 10 , ubiquinol (UQH 2 ), has greater bioavailability than ubiquinone, but the effects of UQH 2 supplementation on mitochondrial respiratory fu...

Scleractinian corals exhibit wide intra‐specific phenotypic variations. However, the extent to which these variations are explained by genotypic variation or phenotypic plasticity remains unclear. To elucidate this question, we devised a replicated experiment in which nine Montipora capitata coral colonies were cut into six pieces each, three of which were placed in shaded conditions (with a 73% reduction in light intensity) w...

Marine heatwaves (MHWs) are increasingly prevalent oceanic extremes with the potential to influence adjacent weather and climate over land. This study characterizes the spatio‐temporal variability of MHWs surrounding New Zealand from 1982 to 2020 and examines their relationship with concurrent terrestrial temperature and rainfall anomalies, alongside the broader synoptic‐scale circulation. This observational analysis reveals a...

Late presentation of ovarian cancer continues to pose a major challenge, as the disease typically manifests with vague and misattributed symptoms. Public awareness initiatives have sought to address this through the use of succinct, symptom-based messaging. The BEAT acronym – Bloating, Eating difficulties, Abdominal pain, Toilet changes – has been developed as a public health tool to promote symptom recognition and timely acti...