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Integrating genome-wide and epigenome-wide associations for antipsychotic induced extrapyramidal side effectsNARA Subscribed
Rationale Antipsychotic medications are the first-line treatment for schizophrenia. Around 40% of people who are treated with antipsychotics could develop extrapyramidal side-effects (EPSE) including: (1) Dyskinesia, (2) Parkinsonism, (3) Akathisia, and (4) Dystonia. Objectives This study aimed to identify genetic risk factors for EPSE presence following antipsychotic treatment. Methods We conducted Genome-wide association (GW...
Longitudinal Impacts of Forest Loss on Bartonella and Hemotropic Mycoplasma Dynamics in Vampire Bats Within a Fragmented HabitatNARA Subscribed
Habitat fragmentation can negatively impact wildlife, including increasing infectious disease risk. We assessed spatiotemporal changes in pathogen dynamics in vampire bats ( Desmodus rotundus ) in response to habitat fragmentation using general linear mixed models to investigate the influence of site, year, and tree cover on Bartonella spp. and hemotropic Mycoplasma spp. (hemoplasmas) infection risk in bats in one large and on...
Symbiodiniaceae and Bacterial Microbiome Dynamics Differentially Impact the Survival of Dominant Reef‐Flat Porites CoralsNARA Subscribed
Coral reefs face significant threats across the globe, prompting a surge in restoration efforts aimed at mitigating their global decline. The health, resilience, and adaptability of corals are greatly influenced by their microbial communities, and while the response of coral microbiomes to many environmental stressors has been extensively studied, less is known about their natural dynamics following transplantation, which is a...
Mixed effect estimation in deep compartment models: Variational methods outperform first-order approximationsNARA Subscribed
This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are associated with significant morbidity in survivors. While better and safer treatments for acute leukemia are urgently needed, standard drug development pipelines are lengthy and drug repurposing therefore provides a promising approach. Our previous evaluation of FDA-approved drugs for their antileukemic activity...
As coral reefs continue to decline due to anthropogenic stressors, community characterizations will reveal both historical selection processes and adaptive potential to environmental change. To address the potential role of color in the distribution and resilience of massive Porites corals, we surveyed the distributions of two dominant color morphs (brown and purple), and a unique intermediate state, across a depth gradient in...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Edward Armitage Robinson 1921 – 2013NARA Subscribed
The diurnal cycle of marine cloud feedback in climate modelsNARA Subscribed
Maladaptation and phenotypic mismatch in hatchery‐reared Atlantic salmon Salmo salar released in the wildNARA Subscribed
Changes in body shape, fluctuating asymmetry ( FA ) and crypsis were compared among Atlantic salmon Salmo salar fry kept as controls in captivity and those released and subsequently recaptured in the wild according to a before‐after‐control‐impact ( BACI ) design. Hatchery fish that survived in the wild became more cryptic and displayed a much lower incidence of fin erosion and of asymmetric individuals than control fish kept...
Vegetable oils (Vo) are an alternative to fish oil (Fo) in aquaculture feeds. This study aimed to evaluate the effect of dietary soybean oil (Vo diet), rich in linoleic acid, and of dietary fish oil (Fo diet) on the development of spinal deformities under bacterial lipopolysaccharide (LPS)‐induced chronic inflammation conditions in Atlantic salmon, Salmo salar L. Fish [25 g body weight (BW)] were fed the experimental diets for...