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Freshwater turtles are one of the most threatened animal groups in the world, especially in Asia. The Beale’s Eyed Turtle ( Sacalia bealei ) is a highly endangered Chinese species at risk of extinction due to overexploitation for the food and pet trades. Nonetheless, Hong Kong still houses a handful of relatively healthy populations of this species, providing an increasingly rare opportunity to study the population genetics of...
Evaluation of the Anti-Inflammatory Effects of Novel Fatty Acid-Binding Protein 4 Inhibitors in MicrogliaNARA Subscribed
Fatty acid-binding protein 4 (FABP4) is a key lipid binding protein expressed in microglia, which has been demonstrated to play a critical role in microglial-mediated neuroinflammation, a component of many neurodegenerative diseases. Compounds able to inhibit the function of FABP4 have shown promise in reducing microglial-mediated neuroinflammation, however, their physicochemical properties would prevent their ability to be ea...
Ecohydrological Response of a Tropical Peatland to Rainfall Changes Driven by Intertropical Convergence Zone VariabilityNARA Subscribed
Aim Tropical peatlands are globally significant carbon stores, increasingly threatened by human activities and climate change. However, their ecohydrological responses to shifting water availability remain poorly understood. In this study, we investigate the connections between climate change, hydrology and vegetation dynamics in a coastal tropical peatland in Panama, aiming to understand the effects of future drying on peatla...
The biogeography and evolution of land ownershipNARA Subscribed
Aim Land ownership norms are well documented and play a central role in social–ecological systems. Yet only recently has the spatial and temporal distribution of land ownership been examined using biogeographical and evolutionary approaches. We incorporate biogeographical and evolutionary modelling to test associations between land ownership and environmental, subsistence and cultural contact predictors. Location Africa. Taxon...
There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Background Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP), but changes in the underlying control mechanisms across the lifespan are less well understood. We aimed to; (1) examine the impact of age, sex, cardiovascular disease (CVD) risk, and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (2) explore the relationships betwee...