J. Manning results 189
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Conservation (or safe) havens are protected areas where barriers (e.g., fences) separate biodiversity from threatening processes and are being increasingly used to support conservation. Differences between selection pressures inside and outside havens can be anticipated; however, understanding of the evolutionary consequences of these differences is limited, and many changes may be going unnoticed. This hampers assessments of...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Computational Modeling of Flow in an in Vitro Cerebrovascular Model Under Pulsatile Conditions with Experimental ValidationNARA Subscribed
Purpose Computational fluid dynamics (CFD) has been widely used to understand various cardiovascular diseases such as acute ischemic stroke (AIS), which occurs when a blood clot lodges in the cerebrovasculature and obstructs blood flow that may lead to brain damage or death. Compared with medical imaging, CFD can predict hemodynamics and clot migration, which are crucial in better understanding the biomechanics of AIS. To rely...
Locally Reprogramming Tumor-Associated Macrophages with Cytokine-Loaded Injectable Cryogels for Breast CancerNARA Subscribed
Purpose Tumor-associated macrophages (TAMs) are the most abundant immune cells in primary solid tumors, including breast cancer, and typically exhibit an M2-like, immunosuppressive phenotype that promotes tumor growth. Given that TAMs can be repolarized through cytokine signaling, we propose a localized cytokine delivery depot using an injectable alginate cryogel to reprogram TAMs and create an inflammatory, anti-tumor TME. Me...
Nutrient enrichment of aquatic ecosystems typically results in increased algal biomass, but the response magnitude is predicted to be attenuated in light-limited ecosystems. We tested the effects of experimental nutrient enrichment in small, highly shaded forest streams and compared responses of biofilm biomass and biofilm stoichiometry, which may be less sensitive to light. After one year of pre-treatment data collection, we...
Seaweeds provide important macronutrients for marine herbivores and potential for aquaculture. However, the nutritional content of most New Zealand seaweeds is undocumented. Here, the nutritional composition of eleven common, littoral seaweed species in northeastern New Zealand was examined using proximate composition analysis. Overall, red seaweeds were highest in protein and insoluble fibre, brown seaweeds were highest in li...
Spatial distribution of soil organic carbon in an Irish salt marsh (Rogerstown Estuary)NARA Subscribed
Salt marshes are globally widespread, found on low-lying coastal shores, and are highly effective at long-term carbon storage; thus, they are vital for climate change impact mitigation. Accurate carbon stock estimation requires an understanding of local-scale spatial variability of carbon storage and the facilitating processes. Few studies investigate the cumulative impact of controlling factors on within-site carbon distribut...
Cryptotephra from a ~120 ka Tondano eruption in a sediment core from Lake Towuti (Indonesia)NARA Subscribed
Southeast Asia is one of the most volcanically active regions in the world, yet their long‐term eruptive history has been comparatively little studied. In particular, little work has explored the potential of sedimentary archives to record distal cryptotephra, which may help in identifying some of the region's larger Quaternary eruptions. Here, we report the finding of cryptotephra in a sediment core from Lake Towuti (Sulawesi...
Ecological theory predicts that consumers should be co‐limited by resource quantity and quality, given widespread consumer‐resource nutritional imbalances. We used 25 estimates of annual community secondary production (ACSP) of stream macroinvertebrates to assess the relative roles of basal resource quantity (leaf litter standing stock [LLSS]) and quality (% nitrogen and % phosphorus of leaf litter) in modulating patterns of p...
Continental‐scale seston stoichiometry reveals fundamental constraints on the elemental composition of particles transported by streamsNARA Subscribed
Suspended particulate matter, or seston, represents an understudied flux of carbon (C), nitrogen (N), and phosphorus (P) in river networks. Here, we summarize riverine seston C : N : P stoichiometry data from 27 streams and rivers sampled regularly from 2014 to 2022 across the United States by the National Ecological Observatory Network (NEON). We examine relationships among seston C, N, and P content using standardized major‐...
Centering environmental justice in United States (U.S.) National Climate Assessments (NCAs): a historical and contemporary analysisNARA Subscribed
Since 1990, the U.S. Global Change Research Program has published five cross-sectoral National Climate Assessment (NCA) reports. Federal, state, and local governments, policymakers, and the public employ NCAs to analyze climate risks, impacts, and adaptation and mitigation options. This article surveys the NCA landscape and makes the case for centering environmental justice (EJ) to inform actionable, relevant, and accessible c...