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Gentiana gaurii sp. nov. is described from Indian Western Himalayan region (Chamoli district). It is morphologically similar to G. ornata , G. lawrencei , and G. hexaphylla from which differ by both vegetative and sexual characters. A molecular study using the nuclear ribosomal DNA internal transcribed spacers (nrITS) support the recognition of the new species. A diagnosis, detailed taxonomic description, original photos and d...
The negative and cognitive symptoms of schizophrenia are predictive of quality of life and functional recovery, but there are no approved drug options that target these symptoms directly. TAK-041 (also known as NBI-1065846) is a selective and potent small-molecule agonist of GPR139, an orphan G-protein-coupled receptor, which has been shown to reverse deficits related to negative and cognitive symptoms in animal models. In thi...
Glutathione alterations in depression: a meta-analysis and systematic review of proton magnetic resonance spectroscopy studiesNARA Subscribed
Background Major depressive disorder (MDD) is a common and serious psychiatric disorder associated with significant morbidity. There is mounting evidence for the role of oxidative stress in the pathophysiology of depression. Objective To investigate alterations in the brain antioxidant glutathione in depression by undertaking a meta-analysis of proton magnetic resonance spectroscopy (1H-MRS). Methods MEDLINE, EMBASE and Psych...
Estuarine Floc Mass Distributions from Aggregation/Disaggregation and Bed Sediment ExchangeOA Marine
Estuarine benthos, among other lifeforms of interest to water quality, can be sensitive to size-distributed suspended cohesive flocs. In such a context, tide-dependent floc mass distributions in the Tamar Estuary in the UK are revisited. At the field site close to maximum turbidity, time-series of the water level, current velocity, salinity, and suspended sediment concentration (SSC) were recorded in 1998 over several tidal cy...
A study was undertaken at Lake Apopka in Florida to assess the minimum water depth required to contain a wind-induced episodic rise of fluid mud. In a year-long investigation, measurements were made at the mean water depth of 1.3 m to record the variation of suspended sediment concentration due to bed erosion and settling of the flocculated matter. The height of rise is defined as the elevation above the bed at which the mud f...
Purpose of Review Mesenchymal Stromal/Stem Cells (MSCs) include a population of cells that are predominantly stromal cells with a small fraction of mesenchymal stem cells that demonstrate stem-cell like properties. MSCs have great therapeutic potential but are not used frequently in clinical settings because of methodological challenges posed at pre-transplantation stages, issues during post-transplantation detection, and the...
Myocardial infarction elevates endoplasmic reticulum stress and protein aggregation in heart as well as brainNARA Subscribed
Cardiovascular diseases, including myocardial infarction (MI), constitute the leading cause of morbidity and mortality worldwide. Protein-aggregate deposition is a hallmark of aging and neurodegeneration. Our previous study reported that aggregation is strikingly elevated in hearts of hypertensive and aged mice; however, no prior study has addressed MI effects on aggregation in heart or brain. Here, we present novel data on he...