Rationale Antidepressant response to ketamine is greatest in patients with a family history of alcohol use disorder (AUD), but it remains unclear if this trend holds true for a personal history of alcohol use. Objective We hypothesized that a personal history of episodic heavy drinking would positively correlate with antidepressant response to ketamine. Methods In a retrospective cohort study, patients with Major Depressive Di...

Predator–prey interactions are important drivers of adaptation in aquatic communities, shaping the behavior of invertebrates with cascading effects on community dynamics. Behavioral responses, such as moving with the downstream current (drift) or altering the timing of emergence, are strategies that reduce the risk of predator encounters. These prey responses have been extensively studied over the last decades. However, much o...

Genomic studies of species threatened by extinction are providing crucial information about evolutionary mechanisms and genetic consequences of population declines and bottlenecks. However, to understand how species avoid the extinction vortex, insights can be drawn by studying species that thrive despite past declines. Here, we studied the population genomics of the muskox ( Ovibos moschatus ), an Ice Age relict that was at t...