J. Meng results 343
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Standardized microhaplotype databases and frameworks for assessing and mining crop genetic diversityNARA Subscribed
Keymessage Standardized microhaplotype databases for eight diverse crops enable multiallelic analyses, comparative genetics, and breeding decisions. Abstract Microhaplotypes are short genomic segments that contain multiple tightly linked variants, providing multi-allelic data that can enhance genetic resolution compared to traditional biallelic single nucleotide polymorphism (SNP) markers. Here, we present the creation and uti...
The immunogenic potential of AZD1402 (Elarekibep) T-cell epitopes in healthy volunteers and drug-exposed clinical trial participantsNARA Subscribed
AZD1402 (Elarekibep) is a novel anticalin with engineered IL-4Rα antagonist binding properties that was under development for inhaled treatment of asthma. Structural similarity to tear-lipocalin is thought to limit immunogenicity risk; however, a range of treatment-emergent hypersensitivity-like adverse events were observed in a clinical study. This study aimed to (i) explore the activation of drug-exposed human T-cells with A...
Aim East Asia spans temperate to tropical zones, with limited glacial influence and a complex geological history shaped by the Tibetan Plateau. Consequently, species here may show distinct phylogeographic patterns compared with those of Europe and North America. Using the warm‐adapted cladoceran Diaphanosoma dubium as a model, we tested whether it persisted in multiple watershed refugia, especially the Yangtze River Basin, dur...
Precision measurement of the Ds*+-Ds+ meson mass differenceNARA Subscribed
Plants employ multiple strategies to adapt to their growth environment. Characterizing key dimensions in plant trait space is important for understanding functional diversity within ecosystems. Leaf and root functional traits have been studied in the context of resource economics, but whether they covary, and through which mechanisms, is still debated. We investigated this in subtropical forests by sampling root and leaf trait...
Twenty-four-hour blood pressure and CSF biomarkers of Alzheimer’s disease and related dementias in a community cohortNARA Subscribed
Hypertension in midlife is associated with increased dementia risk, yet its relationship with early pathological changes of Alzheimer’s disease and related dementias (ADRD) remains unclear. Unlike office blood pressure (BP), 24-h ambulatory BP (ABPM) may better reflect cardiovascular risk, but associations between 24-h BP measures with ADRD biomarkers are unknown. This cross-sectional study examined associations between BP and...