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Myocardial infarction (MI) remains a leading cause of heart failure, and current therapies fail to prevent cardiomyocyte loss or support effective tissue regeneration. Injectable hydrogels (HGs) have emerged as promising platforms for delivering therapeutic cues and structural support; however, few systems simultaneously integrate vascular guidance and RNA therapeutics. Here, we have developed a thermosensitive alginate-collag...
Detection of downy mildew infection in grapevine leaves using field spectroscopy and machine learningNARA Subscribed
Context Downy mildew, caused by Plasmopara viticola , remains one of the most damaging diseases affecting grapevines, especially in humid viticultural regions such as the “Vinhos Verdes” in northern Portugal. Traditional detection relies on visual inspection and laboratory techniques, which are subjective and reactive, often delaying effective intervention. Aims This study aims to evaluate the potential of field spectroscopy c...
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitisNARA Subscribed
Fungal keratitis (FK), caused by fungi like Aspergillus , Fusarium , and Candida , accounts for 20–60% of microbial keratitis cases and over 1 million visual impairments annually. Voriconazole (VOR) is effective against FK, but its eye drop formulations suffer from poor bioavailability, while intrastromal injections are invasive and carry risks. This study aimed to address these challenges by formulating a VOR nanosuspension (...