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Microtubules, essential components of the cytoskeleton, are assembled from α/β-tubulin subunits by the γ-tubulin ring complex (γ-TuRC). Over the last five years, cryo-electron microscopy studies have advanced our structural and mechanistic understanding of this process by elucidating structures of the γ-TuRC from different organisms and, very recently, after microtubule nucleation under varying conditions.
Autophagy alleviates amiodarone-induced hepatotoxicityNARA Subscribed
Amiodarone is a widely used antiarrhythmic drug that can cause the development of steatohepatitis as well as liver fibrosis and cirrhosis. The molecular mechanisms of amiodarone-mediated liver injury remain largely unknown. We therefore analyzed amiodarone-mediated hepatocellular injury in patients with chronic heart failure, in primary hepatocytes and HepG2 cells. We found that amiodarone-treated patients with chronic heart f...
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