Reef-building corals can shift from autotrophic to heterotrophic feeding during episodic heatwaves, which may have mitigating effects on thermal stress. It is yet unclear to what extent this could occur during early life stages of corals, and how this affects survival. We exposed settlers (primary polyps) of the Caribbean Golf ball coral Favia fragum to a lab-controlled heatwave lasting 48 days under two feeding regimes (36 ve...

The disease course and outcome of COVID-19 greatly varies between individuals. To explore which biological systems may contribute to this variation, we examined how individual metabolites and three metabolic scores relate to COVID-19 outcomes in hospitalized COVID-19 patients. The metabolome of 346 patients was measured using the 1H-NMR Nightingale platform. The association of individual metabolomic features and multi-biomarke...

This work focusses on extending the deep compartment model (DCM) framework to the estimation of mixed-effects. By introducing random effects, model predictions can be personalized based on drug measurements, enabling the testing of different treatment schedules on an individual basis. The performance of classical first-order (FO and FOCE) and machine learning based variational inference (VI) algorithms were compared in a simul...