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Habitat fragmentation is a key driver of reduced genetic connectivity and loss of genetic variation among populations, elevating the risk of inbreeding depression and reduced adaptive potential. The black-throated finch ( Poephila cincta ) is an endemic Australian finch with two recognised subspecies, a northern ( P. c. atropygialis ) and southern form ( P. c. cincta ) separated by a biogeographic barrier in northern Australia...
The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservationNARA Subscribed
The International Mouse Phenotyping Consortium (IMPC) is building a catalogue of mammalian gene function by producing and phenotyping a knockout mouse line for every protein-coding gene. To date, the IMPC has generated and characterised 5186 mutant lines. One-third of the lines have been found to be non-viable and over 300 new mouse models of human disease have been identified thus far. While current bioinformatics efforts are...
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